[1] RH domains are present in several human proteins involved in regulation of autophagy and endosomal trafficking.

[2] While not all RH domains have been characterized, those of human Rubicon and PLEKHM1 mediate interaction with the small GTPase Rab7, which is found on late endosomes and autophagosomes.

[2][3] Amino acid residues toward the C-terminus of the RH domain of Rubicon have been shown to be essential for interaction with Rab7.

[2] The 3D atomic structure of the Rubicon RH domain in complex with Rab7 has been determined by X-ray crystallography.

[2] The structure is predominantly alpha helical, with short beta strand regions present in the vicinity of zinc finger motifs.