He has worked with James Harman, Roomful of Blues, the Big Rhythm Combo, The Fabulous Thunderbirds, The Mannish Boys, Bobby Jones and Los Fabulocos.

David Ramos was born in Fullerton, California, United States, with both of his parents being professional opera singers.

After playing at the parties of friends and at local nightclubs in his teenage years, he turned fully professional when joining James Harman's band in 1980.

As well as regularly recording and appearing with them up to 2002, Ramos also continued to release his own albums, with Greasy Kid Stuff (2001) being his most recent.

In August 2012, Ramos was diagnosed with Ewing's sarcoma,[3] a rare form of cancer, and underwent chemotherapy treatment the following month.