Other notable series during the block's WB run included Animaniacs (a Fox Kids carryover) and spinoff Pinky and the Brain (which began as a WB prime time series), Freakazoid!, The New Batman/Superman Adventures, Histeria!, Cardcaptors, Yu-Gi-Oh!, Jackie Chan Adventures, Static Shock, and Johnny Test.

The block moved to The CW (a result of the merger of Time Warner-owned The WB and CBS Corporation-owned UPN) upon its launch in September 2006.

Following a 13-year run on broadcast television, on May 24, 2008, Kids' WB was replaced by successor block The CW4Kids (later renamed Toonzai in 2010) under a time-lease agreement reached between The CW and 4Kids Entertainment to take over programming the network's Saturday morning timeslot.

Some WB affiliates (such as WPIX in New York City, KTLA in Los Angeles and KWGN-TV in Denver) aired the weekday morning and afternoon lineups together as an expanded three-hour block, running from 2:00 to 5:00 p.m. On the same date, the block received an on-air rebranding – which included a revised logo and graphics package centered upon the Warner Bros. Studios lot theme that was also used in promotions for The WB's primetime programming during the network's first eight years on the air – which was developed by Riverstreet Productions, and lasted until 2005.

On February 13, 1999, Kids' WB made a breakthrough when the English dub of the anime series Pokémon by 4Kids Entertainment moved to the network from broadcast syndication.

In July 2001, Kids' WB's weekday afternoon lineup was rebranded as Toonami on Kids' WB, extending the Cartoon Network action-animated block Toonami to broadcast television, and bringing shows such as Sailor Moon, Dragon Ball Z, and The Powerpuff Girls to broadcast network television.

However, the sub-block was critically panned by industry observers, who noticed that the action branding of the block - which had added shows such as Generation O!, Scooby-Doo, and The Nightmare Room, a live-action series created by Goosebumps author R. L. Stine - did not translate content-wise.

On May 31, 2005, The WB announced that the weekday afternoon Kids' WB block would be discontinued "at the request of the local affiliates," as it became financially unattractive due to the fact broadcast stations perceived that children's programming viewership on afternoon timeslots had gravitated more towards cable networks – these stations began to target more adult audiences with talk shows and sitcom reruns in the daytime.

As a result, the Saturday morning Kids' WB lineup that remained was extended by one hour on January 7, 2006, running from 7:00 a.m. to noon, no longer affected by time zone variances.

Notably, during this time AOL-then a sister company to Warner Bros.-was the main sponsor of CBS' own Saturday morning block KOL Secret Slumber Party, but at no point did neither Kids' WB nor SSP advertise each other's programs-most likely because SSP was produced and operated by DIC Entertainment and was aimed at girls, as opposed to the boy-centric Kids' WB.

[5] On October 2, 2007, The CW announced that it would discontinue the Kids' WB programming block through a joint decision between corporate parents Time Warner and CBS Corporation, due to the effects of children's advertising limits and cable competition; the network also announced that it would sell the five-hour Saturday programming slot to 4Kids Entertainment.