Her work has included multiple audio and video programs, including the This Week in Science radio program and podcast and Dr. Kiki's Science Hour, a podcast involving interviews with experts in a given scientific field.

Davis, she found academic bureaucracy unappealing and decided to shift her career path from research to science communication.

[5] Sanford lived in San Francisco with her husband until moving to Portland, Oregon in April 2015.

Sanford says of her work, "My shtick is: Dr. Kiki reaches out to people who don't necessarily like science to get them to see it as something enjoyable.

Starting in late 2007, Sanford expanded her work, starring in On Network's successful series Food Science.

[9] In May 2008, Sanford along with several other skeptics and scientists created a pilot for a TV series titled The Skeptologists.

Guests included scientists, skeptics, and science communicators such as astronomer Phil Plait and neurologist Steven Novella.