Kirki railway station (Greek: Σιδηροδρομικός Σταθμός Κιλκίς, romanized: Sidirodromikós stathmós Kirki) is a railway station in the small town of Kristoni, that serves the nearby town of Kilkis, both in Kilkis in Central Macedonia, Greece.

On 1 January 1971, the station and most of the Greek rail infrastructure were transferred to the Hellenic Railways Organisation S.A., a state-owned corporation.

Freight traffic declined sharply when the state-imposed monopoly of OSE for the transport of agricultural products and fertilisers ended in the early 1990s.

[4] In 2003, OSE launched "Proastiakos SA", as a subsidiary to serve the operation of the suburban network in the urban complex of Athens during the 2004 Olympic Games.

In July 2022, the station began being served by Hellenic Train, the rebranded TranOSE[6] It is served by long-distance and Intercity services between Thessaloniki and Alexandroupolis, and Regional services to Ormenio Between July 2005 and February 2011, the Friendship Express, (an international InterCity train jointly operated by the Turkish State Railways (TCDD) and TrainOSE linking Istanbul's Sirkeci Terminal, Turkey and Thessaloniki, Greece) made scheduled stops at Kilkis.