Commercially, "Kill This Love" peaked at number two on the Gaon Digital Chart and the Billboard K-pop Hot 100 in South Korea.

The song has been certified double diamond in Brazil, platinum in South Korea, Japan, Australia, and New Zealand, gold in France, and silver in the United Kingdom, among others.

An accompanying music video for the song was directed by Seo Hyun-seung and uploaded onto Blackpink's YouTube channel simultaneously with the single's release.

Erica Russell from Paper gave a glowing review, ranking "Kill This Love" as the best song of 2019 and praised it as a "perfect" sonic blend of all the group members and an "explosive culmination" of the musical trends that dominated the past decade.

[14] Conversely, Michelle Kim from Pitchfork gave it an unfavorable review, describing the song's production as strangely out of date and suggesting it could have been produced in the early 2010s.

[9] Rhian Daly from NME expressed disappointment with the track's production, labelling the chorus as uninspiring and a letdown following the song's initial buildup.

[26] In May 2021, the song was certified silver by the British Phonographic Industry (BPI) for moving 200,000 single-equivalent units, the group's first solo single to do so.

[28] In 2021, "Kill This Love" also became Blackpink's second song to surpass 500 million streams on Spotify after "How You Like That" and the second by any female Korean group to reach this mark.

[42] It earned the biggest music video debut in YouTube history with 56.7 million views within 24 hours of release, surpassing the record held by Ariana Grande's "Thank U, Next" (2018).

[43] Furthermore, it became the fastest video to reach 100 million views on YouTube, doing so in approximately 2 days and 14 hours, beating the record set by fellow Korean artist Psy with "Gentleman" in 2013.

[47] South Korean public broadcaster KBS banned the music video "for violating the country's Road Traffic Act", due to a scene in which Rosé is seen driving a car at high speed without a seatbelt.

[49][50] "Kill This Love" and other songs of the same-titled EP were performed at the Coachella Valley Music and Arts Festival in Indio, California on April 12, 2019.