[5] She influenced the planning and construction of LECOM Harborcenter, a mixed-use development next to the Sabres' arena and part of the revitalization of downtown Buffalo.

The Pegulas competed with Donald Trump and also a consortium of rock singer Jon Bon Jovi and key people in Toronto-based Maple Leaf Sports and Entertainment for the team.

The Pegulas have also donated significant amounts of money to their alma maters, including $12 million to Houghton College, which allowed it to build a new athletics complex and transition to NCAA Division III.

[citation needed] In March 2018, Pegula was named to the National Football League's business ventures committee, replacing Russ Brandon.

[12] Pegula remained president of the organization and its properties until its dissolution in 2023, which occurred after a major health incident in 2022 that left her unable to fulfill her duties.

[13] Pegula is also one of a handful of female NFL owners, including Sheila Ford Hamp (Detroit Lions), Virginia Halas McCaskey (Chicago Bears), Amy Adams Strunk (Tennessee Titans), Carol Davis (Las Vegas Raiders), Denise DeBartolo York (San Francisco 49ers), Gayle Benson (New Orleans Saints), Janice McNair (Houston Texans), Jody Allen (Seattle Seahawks) and Dee Haslam (Cleveland Browns).

Jessica Pegula credited her sister, Kelly, for saving their mother's life as she had taken a CPR class just months prior.

Her assets were placed into a trust managed by Terry and his longtime business partner Bob Long, while her stepdaughter Laura Pegula assumed Kim's role as Bills co-owner in early 2024.

[4] A year later in July 2024, she publicly took steps outside her vehicle, assisted by her husband, and broke down the huddle following the Bills' training camp practice that day.