She worked at HP Labs as a Distinguished Technologist and is currently employed by Google as Principal Engineer, and was one of the designers of the Express Query metadata database used by Hewlett-Packard as part of their StoreAll large-scale data storage systems.
Her dissertation, Computer Architecture Support for Database Applications, was supervised by David Patterson.
[2] A paper written by Keeton in 2004 with four other researchers on the automated design of disaster-resistant enterprise storage systems won the Usenix FAST Test of Time Award in 2018.
[3] She also won the 2018 SIGMOD best paper award for her work with other collaborators on "range filtering" data structures that combine the memory-efficient filtering abilities of bloom filters with the ability of range query data structures to find data with a range of key values rather than with a single exactly matching key.
[4] Keeton was elected as an ACM Fellow in 2018 for "contributions to improving the dependability, manageability, and usability of storage and novel memory".