[2] The phosphate groups are usually added to serine, threonine, or tyrosine amino acids on the protein.
[3] Phosphorylation regulates many biological processes, and protein kinase inhibitors can be used to treat diseases due to hyperactive protein kinases (including mutant or overexpressed kinases in cancer) or to modulate cell functions to overcome other disease drivers.
Kinase inhibitors such as dasatinib are often used in the treatment of cancer and inflammation.
[6] There are several drugs launched or in development that target protein kinases and the receptors that activate them: Note: AD = Approval date.
- means 0-10% of patients exhibit this side effect.