It is located on Missenden Road in Camperdown, directly opposite the main buildings of the much larger Royal Prince Alfred Hospital with which it was amalgamated on 14 November 2002.

King George V hospital, opened in 1941, was designed in the Inter-War International Art Moderne style by prominent Sydney architects Stephenson & Turner.

Of an especially innovative design, the building was awarded the 1941 Sir John Sulman Medal by the Royal Australian Institute of Architects (NSW Chapter).

[2] After serving in its intended role for 61 years the old King George V Memorial Hospital was, in 2002, amalgamated back into the (much larger) Royal Prince Alfred Hospital from which it had been separated in 1941.

Maternity services were transferred into a larger newly built wing on the other side of Missenden Road and the original building was refurbished to house hospital administration offices for Royal Prince Alfred, including Human Resources and Staff related services.