[3] This species inhabits Afrotemperate forests of the West Usambara Mountains at elevations of 1,200–2,500 m (3,900–8,200 ft) above sea level.

[1] The forest patches suffer from timber removal and resource utilization, and habitat is being lost to encroachment and transformation for agriculture.

Like other chameleons, K. multituberculata is listed on CITES, meaning that legal international trade requires a permit.

[1] After its recognition as a separate species by CITES, Tanzania initially allowed limited legal exports of K. multituberculata, but stopped it after 2017.

[4] K. multituberculata is one of the larger species in the genus Kinyongia at up to 34 cm (13 in) in total length, with the tail making up more than half of that.