The mission of St. Paul Major Seminary, Kipalapala is to impart academic, religious, moral and human training to young persons who will serve the Catholic Church and the nation as committed priests.

[2] The vision of St. Paul's Major Seminary is a deep evangelization of the local Catholic Church of Tanzania through a well trained personnel.

Two years later the seminary was shifted to Kipalapala, Tabora, a place which was central and accessible for students who came for priestly formation not only from Tanzania (Tanganyika by then) but also from neighboring countries such as Kenya, Malawi and Zambia.

[3] In the years that followed World War I the White Fathers decided that a regional seminary should be founded at Kipalapala to serve the apostolic vicariates of Tabora, Nyassa, Bangwelo and Tanganyika.

Bishop Mathurin Guillemé, vicar apostolic of Nyassa, was one of the driving forces in establishing the regional seminary at Kipalapala.