[10][17] He oversees ProViotik, which is a Bulgarian business that has found success in the American, European, and Asian markets by developing cutting-edge bioproducts in collaboration with experts from across the globe.

He developed a probiotic based on the Bulgarian strain of Lactobacillus bulgaricus, which is extracted from snowdrops and is then cultivated in carrot juice rather than milk.

[21] In order to maintain the stability of the Bulgarian economy, he stated that he will strive for transparency, professionalism, and responsible conduct in the upcoming months.

[21] Petkov, together with Asen Vasilev, proposed a scheme at the beginning of the COVID-19 pandemic to enable firms to continue operating, with employees undergoing testing on a regular basis to prevent the need to close.

[22] In his first television appearance as a minister, Petkov revealed that the state-controlled Bulgarian Development Bank had distributed 500 million euros in loans to just eight companies owned by four businessmen.

[27] Political opponents of Petkov, which included Lozan Panov, a presidential candidate and chairman of the Supreme Court of Cassation of Bulgaria, called for action to be taken on the issue.

[28] Petkov was previously a citizen of Canada, and stated that he had renounced his citizenship in April 2021, but Canadian government documents showed that the procedure was not officially completed until August 2021.

The coalition is in agreement that the state's governance reforms should continue, adhering to the zero corruption concept and halting the opaque leaking of public funds.

The coalition's primary objectives are to establish an economic climate that facilitates the unrestricted growth of small and medium-sized enterprises, draw in high-tech, strategic investments, distribute public resources fairly and equitably, and uphold the rule of law.

The statement stated that the union will prioritise funding for high-quality education, the creation of more accessible and inexpensive health care, contemporary infrastructure, and social policies that guarantee adequate incomes for the elderly.

[31] He later said he wanted to pursue "transparent" coalition negotiations with Democratic Bulgaria (DB) and There Is Such a People (ITN), and that he would be PP's nomination for prime minister,[32] and wished to exclude DPS and GERB.

[34] On 10 December, the leaders of the four parties confirmed that they had reached a coalition agreement, and would form Bulgaria's first regular government since the election in April 2021.

[61] Petkov formally resigned from his position as prime minister on 27 June, and was tasked by President Rumen Radev to form a new government.

[74] Petkov noted Bulgaria's espousal of all sanctions against Russia, and would allow the use of the Port of Varna to transship goods that had been stifled by the Russian blockade of Odesa.

[81] Kiril Petkov then stated on 8 July 2022, that his centrist party would probably have to abandon its intentions to present a new administration due to its inability to get a legislative majority.

Petkov emphasised during a news conference held at the National Assembly that Bulgaria is seeking admission without requiring a fresh vote in the European Council and that the country is concentrating on creating the circumstances necessary for automatic inclusion.

[83] In 2024, his speech to the World Economic Forum in Davos, Kiril Petkov stressed that cooperative infrastructure development may help Bulgaria, Romania, and Greece attain the highest GDP growth in Europe.

During a conversation hosted by "Greek House Davos" with the topic "Rethink the Ports as Hubs: The Strategic importance for Greece, Balkans and Europe," Petkov emphasised the need of interconnected infrastructure in promoting prosperity and economic independence.

He also emphasised Bulgaria's accomplishment of reducing its 95% reliance on Russian gas to 0%, noting a variety of energy sources as a crucial element in attaining political and economic independence and claiming that the Balkans might achieve the highest GDP growth in Europe with the construction of vital infrastructure.