Kirill Rozum was born into the Razumovsky family, at that time low-rank family of Cossack Grigory (Hryhoriy) Rozum in the settlement of Lemeshi in the Kiev Regiment [ru] (now in Chernihiv Raion, Chernihiv Oblast, Ukraine) on 18 March 1728.

Teplov wielded influence over Little Russia in his capacity as the secretary and advisor to Kirill Razumovsky (whose cousin he married).

Kirill Razumovsky died in January 1803 in Baturin, where he was interred according to his wishes without any pomp, in stark contrast to his rather flamboyant lifestyle.

However, Andrey has become better known for his role as patron of Ludwig van Beethoven who dedicated three String Quartets, Op.59 1, 2 and 3, as well as the 5th and 6th Symphonies to him.

Any living descendants in the male line of Kirill Razumovsky arise from the progeniture of his fourth son Gregory Razumovsky (1759–1837), who had to emigrate to Western Europe and acquired relative fame as natural scientist and member of a number of distinguished scientific societies in Austria, Prussia and Switzerland.