Kirkconnel is situated on the former Glasgow and South Western Railway main line between Kilmarnock and Carlisle.

A plaque at the station commemorates Alexander Anderson, the poet from Kirkconnel, who rose from being a railway worker to become Chief Librarian at the University of Edinburgh.

[3] On Monday to Saturdays, there are nine trains per day in each direction towards Dumfries (six of these continue to Carlisle) and Glasgow Central running on a mostly two-hourly frequency.

There was previously one train a day to Newcastle on Monday to Saturdays, however this was stopped in the May 2022 timetable change.

This article about a railway station in the Dumfries and Galloway council area of Scotland is a stub.