Though writing was her main and most preferred activity and she considered herself primarily a writer, she also worked as a teacher (as an inspector or a visitator) of female schools, and lecturer in moral science at the Governess' Institute in Warsaw (1826–1831).

During the November Uprising of Polish people against the Russian Empire, Hoffmanowa was a co-creator and chairman of the Union of Patriotic Charity of the Varsovians and carried the help to the wounded soldiers.

In Paris, Hoffmanowa was active in the Charity Association of Polish Ladies and the Literary Society, and was called “the Mother of the Great Emigration”.

In 1829 she married Karol Boromeusz Hoffman, writer, lawyer and historian, and changed her name to Hoffmanowa, a marital form of her husband's surname.

After Poland's November Uprising against the Russian Empire was crushed in the second half of 1831, Hoffmanowa moved with her husband to Dresden, and later settled in Paris.