He played college football for the Texas Tech Red Raiders, finishing in the top three in several school passing records before being selected in the sixth round of the 2003 NFL draft by the New England Patriots.

Kingsbury has been cited for his work in developing quarterbacks Case Keenum, Johnny Manziel, Baker Mayfield, Patrick Mahomes, Kyler Murray, Caleb Williams, and Jayden Daniels.

[3] As a quarterback at New Braunfels, Kingsbury threw for 3,009 yards and 34 touchdowns while leading the team to the Class 5A Division II semifinals and a 13–2 record.

[2] Kingsbury played 43 games at quarterback for the Texas Tech Red Raiders from 1998 to 2002, completing 1,229 of 1,881 passes for 12,423 yards with 95 touchdowns and 40 interceptions.

In his redshirt freshman year in 1999, Kingsbury appeared in six games, starting the season finale against Oklahoma.

As a junior in 2001, Kingsbury was an All-District first-team selection and All-Big 12 Conference second-team pick by the league's coaches for his performance.

[7] These awards followed a season during which he shattered his own school single-season records by completing 479 of 712 passes (67.3 percent) for 5,017 yards, 45 touchdowns and just 13 interceptions.

[6] Kingsbury made his NFL debut on November 20, 2005, playing part of the fourth quarter for the Jets against the Denver Broncos.

He spent part of training camp in Montréal before being traded to the Winnipeg Blue Bombers on June 20 in exchange for quarterback Brad Banks.

[19] Kingsbury was named the offensive coordinator for the Texas A&M Aggies in 2012, coaching Heisman Trophy-winning quarterback Johnny Manziel.

Mayfield was later supplanted by Davis Webb, another true freshman quarterback, due to a knee injury during the Kansas game.

[26] The Red Raiders made their Associated Press Top 25 debut in the Kingsbury era following a win over TCU on September 12, 2013.

Following a victory against West Virginia on October 19, 2013, Kingsbury led the Red Raiders to a 7–0 start for only the fourth time in program history.

Tight end Jace Amaro was also named as a Consensus All-American, the first Red Raider to be selected as such since Michael Crabtree in 2008.

[29] Kingsbury and the Red Raiders capped off the season with a 37–23 upset over the #14 ranked Arizona State in the 2013 Holiday Bowl following an impressive performance by quarterback Davis Webb.

[35] The team showed signs of improvement as the offense finishing #16 in the country overcoming the loss of first round pick Patrick Mahomes.

[42] He left with an overall record of 35–40 (including 13 victories over lower tier Group of Five and FCS competition) and 19–35 in Big 12 play.

[46][47] Kingsbury won his first game against the Cincinnati Bengals and finished the season 4th in the NFC West with a record of 5–10–1.

In his playoff debut, Kingsbury and the Cardinals lost 34–11 in the first round to the eventual Super Bowl champion Los Angeles Rams.

Despite signing a six-year contract extension earlier in 2022, Kingsbury was fired after the Cardinals posted a 4–13 record that year.

Kingsbury joined the USC Trojans as a senior offensive analyst under head coach Lincoln Riley in April 2023, where he worked with quarterback Caleb Williams.

[49] On February 5, 2024, Kingsbury was hired by the Washington Commanders as offensive coordinator under head coach Dan Quinn.

[51] Working with rookie quarterback Jayden Daniels, who set the rookie record for most rushing yards in a season at his position, Washington's offense tied for the franchise's second most total points in a season (485) and ranked among the top three in rushing and total yards in team history.