Klondike is a 1932 American pre-Code film directed by Phil Rosen about a man who is put on trial for manslaughter after a surgery on a patient's brain goes awry.

Doctor Robert Cromwell (played by Lyle Talbot) is charged with murder when a patient dies after an experimental operation to remove a brain tumor.

His pilot friend, Donald Evans (Frank Hawks), convinces "Doc" to join him on a trans-Pacific trip as a means to start a new life.

Mark Armstrong (Henry B. Walthall) begs the doctor to attempt the operation on his son Jim (Jason Robards Sr.) who is crippled by a similar brain tumor.

When the doctor refuses, Mark accuses him of wanting his son to die, because he is in love with Jim's fiancée, Klondike (Thelma Todd).