Kluizen is a village in the municipalities of Evergem and Ghent in the province of East Flanders, Belgium.

The area around Kluizen used to be a wilderness of heath and sand grounds.

Between 1115 and 1119, the land was donated to the Ename Abbey by Baldwin VII, Count of Flanders for cultivation and the construction of church.

World War I and II also caused severe damage to the village.

Another annexation by Ghent followed in 1964, and the remainder was merged into Ertvelde, because it was considered too small to be independent.