The film stars Mackenyu, Famke Janssen, Madison Iseman, Diego Tinoco, Mark Dacascos, Nick Stahl, and Sean Bean.

Kido tells Seiya that he should train under Marin the Silver Knight, so that he can use his Cosmo to protect himself and Sienna, and to find Patricia.

Guraad becomes unable to watch Sienna be drained of her energy and tries to stop the procedure, but Nero turns against her and assumes his Phoenix Knight armor.

Nero and Seiya proceed to fight, but are interrupted by Sienna, who has almost completed her transformation into Athena, causing widespread destruction.

[7] The main cast was announced in September 2021, including Mackenyu, Madison Iseman, Sean Bean, Diego Tinoco, Famke Janssen, Nick Stahl, and Mark Dacascos.

The website's consensus reads: "The animation's well done, but impressive visuals aren't enough to cover for Knights of the Zodiac's threadbare plot.

"[15] Metacritic, which uses a weighted average, assigned the film a score of 35 out of 100, based on eight critics, indicating "generally unfavorable" reviews.

[16] Carlos Aguilar of the Los Angeles Times wrote, "That Bagiński's Knights of the Zodiac amounts to a well-intended disappointment doesn't mean it has zero merit as a work of entertainment, but it will neither satisfy the fandom's demands for a true-to-the-bone homage to their childhood favorite, nor will it transmit to outsiders why this tale of blind courage in the face of insurmountable odds has inspired such decades-long devotion.

"[17] Courtney Lanning of the Arkansas Democrat-Gazette said, "The narrative and characters are swallowed by a storm of ill-conceived CGI and unfortunate writing, another title in the long list of live-action anime adaptations that should deter similar future attempts.

"[18] IGN's Matt Donato gave the film a score of 4/10, calling it "a smorgasbord of unimpressive digital effects as Baginski struggles to recreate the feel of anime in live action (think Netflix's Cowboy Bebop show), boiling down Kurumada's vivid source material into a bland, loud, voiceless gruel with no substance.

"[19] Eric Francisco of Inverse praised the film, saying that it was "secretly brilliant in its holistic understanding of what makes anime appealing as a medium."

"[20] Common Sense Media's Tara McNamara gave the film 3/5 stars, likening it to a mashup of Clash of the Titans and Flash Gordon and saying, "Like those two movies, Knights of the Zodiac is likely to get groans from jaded adults, but it has that same potential to strike a chord with young viewers taken in by the spectacle and the possibility.