It is home to the Knott County Central Patriots, who have claimed several regional titles in basketball, baseball, track, volleyball and other sports.

The lower spot cleared off to the left of the school was only used to practice the marching band routines.

The school's speech team, which has 21 regional titles, has captured the KHSSL (Kentucky High School Speech League) State Championship in 2004, 2005 and most recently in 2024 under head coach Bria Stacy, as well as The Smokey Mountain National Invitational Championship 4 times, the most recent being 2009.

In March 2010 the Knott County Central High School's boys' basketball team claimed the 14th region championship title, taking them to the state tournament for the first time in 17 years.

In 2024 Knott County Central's Lady Patriots volleyball team for the first time in school history captured the 14th region title and went on to win the first round of the KHSAA Volleyball sweet 16 on their home court, the Morton Combs Athletic Complex over Ashland Blazer