The campus is located in 6 miles southeast of Galesburg, Illinois, and serves a mixed small city and rural residential community.

The school is in the Galesburg micropolitan statistical area which includes all of Knox and Warren counties.

[3] Knoxville High School is currently under Academic Early Warning Status.

KHS did not make Adequate Yearly Progress in 2009 on the Prairie State Achievement Examination, a state test that is part of the No Child Left Behind Act.

[4] In 2009 the faculty was 69 teachers, averaging 15.0 years of experience, and of whom 30% held an advanced degree.