It was initially located near the corner of College (formerly Clinton Road) and Deaderick streets,[1] now Rogers Memorial Baptist Church.

[1] The students had limited clinical training and no campus facilities, and it required visits to the nearby Knoxville New City Hospital.

[1][4] Knoxville Medical College founding president was Henry Morgan Green.

[5][7] Other faculty members included William Wallace Derrick, a Black physician whom had previously taught at the medical department at Knoxville College;[1][4] A. G. Edwards; W. H. Moore; John Clear; and J. H.

[1] By 1910, Knoxville Medical College was forced to close, most likely due to the poor educational conditions and its reputation for "mediocrity" in its training.