Koffikro-Afféma is a village in south-eastern Ivory Coast.

It is in the sub-prefecture of Maféré, Aboisso Department, Sud-Comoé Region, Comoé District.

The border with Ghana is six kilometres northeast of the village.

Koffikro-Afféma was a commune until March 2012, when it became one of 1126 communes nationwide that were abolished.

This Comoé District location article is a stub.