[1] In May 1821, along with his cousin, Andreas Metaxas, he was one of the chiefs of the Cephalonian volunteers who disembarked at Glarentza and took part in the siege of Lala.
[5][6] With headquarters in Messolonghi, he ended the disputes between the chieftains of Western Greece and contributed to repel of Mustai Pasha of Skodra's troops.
[8] In 1826 he fought in the anti-piracy operations in the Aegean, as well as in the conflicts in Attica as was chief of the Ionian forces, while in 1827 he participated in the staff of general Richard Church.
[9] During the governorship of Ioannis Kapodistrias, Metaxas served as temporary commissioner of the Cyclades and then participated in the Fourth National Assembly at Argos as a representative of the Peloponnesians.
[10] He was married from 1830 to the daughter of a rich and illustrious Muslim family of Laconia, who was saved from the massive massacres of her co-religionists and converted to Christianity adopting the name Eleni.