Kostanecki acylation

The Kostanecki acylation is a method used in organic synthesis to form chromones[1] or coumarins[2] by acylation of O-hydroxyaryl ketones with aliphatic acid anhydrides, followed by cyclization.

[3] If benzoic anhydride (or benzoyl chloride) is used, a particular type of chromone called a flavone is obtained.

It was named after Polish chemist Stanisław Kostanecki.

The mechanism consists of three well-differentiated reactions:[4][5]