Koto Hoxhi was born in Qestorat in 1824 (Gjirokastër District, southern Albania, then Ottoman Empire).

He and Sami Frashëri, Vaso Pasha and Jani Vreto devised an alphabet for expressing the Albanian language.

[3] For these activities Koto Hoxhi came into trouble with the Greek consulate of Ioannina and was excommunicated by the bishop of Gjirokastër of the Ecumenical Patriarchate of Constantinople.

[citation needed] Hoxhi had been on the Central Committee the defence of the rights of the Albanian people which supported the ideas of the League of Prizren.

Other members included Pandeli Sotiri, Hasan Tahsini, Pashko Vasa, Jani Vreto, Sami Frashëri and Abdyl Frasheri.