Koyukuk (/ˈkaɪjəkək/) (Koyukon: Meneelghaadze’ T’oh [məniːlʁæːt͡səʔ tʼoh]) is a city in Yukon-Koyukuk Census Area, Alaska, United States.

[4] The Koyukon Athabascans had seasonal camps and moved when the wild game migrated.

Trading between the Koyukon and Inupiat of the Kobuk River area has occurred before the arrival of Europeans.

Steamboats on the Yukon, which supplied gold prospectors ran before and after 1900 with 46 boats in operation on the river in the peak year of 1900.

A measles epidemic and food shortages during 1900 reduced the population of the area by one-third.

After the school was built, families began to live at Koyukuk year-round.

[10] George Attla (1933–2015), champion sprint dog musher, was born in Koyukuk