[2] It is one of the rarest eco-regions of the world because it harbors vast tracts of pristine mangrove forests.

It is believed by conservationists to be one of the last remaining tracts of thick primary mangrove forests of South India, which is rapidly disappearing due to absence of protective measures.

[3] The sanctuary is a part of the mangrove wetland in Andhra Pradesh and are located in the coastal plain of Krishna River delta.

Some of the tree species in Krishna Wildlife Sanctuary are: Casuarina equisetifolia, Pongamia gladra, Calotropis gigantea, Cassia auriculata, Thespesia populnea, Ipomaea biloba, Spinifex squarrosus, Spinifex littoreus, Pongamia pinnate, Prosopis juliflora, banyan, peepul, margosa, tumma, mango, palmyra.

[citation needed] Fishing cats were recorded between November 2013 and August 2014 at several locations outside Krishna Wildlife Sanctuary.