The hill ranges contain a number of plateaus, of which, Amrabad, Srisailam, Peddacheruvu, Sivapuram, and Nekkanti are noteworthy.

Nagarjunasagar receives rains from the southwest monsoon, which is active from the second half of June to the end of September.

[2] The ancient temples at Srisailam of Lord Mallikarjuna and his consort goddess Bhramaramba, an incarnation of Parvathi as the fair-complexioned boon from Brahma, contain one of the twelve sacred Shaiva Jyotirlingas and one of the eighteen Maha Shakthi peethas in India.

The ruins of a fort of the 3rd century BCE Indian ruler, Ikshwaku Chandragupta overlook the Nirjivapuram (Lifeless city) valley.

Important plant species here are: Anogeissus latifolia (axlewood), Cleisthanthus collinus (odcha), Terminalia spp., Pterocarpus marsupium, Hardwickia binata (anjan tree), Boswellia serrata (Indian frankincense or salai), Tectona grandis (teak), Mundulea sericea and Albizia spp.

In a study (conducted during 2016–2019) that ascertained the economic value of the ecosystem services provided free of cost by the 'Nagarjunasagar Srisailam Tiger Reserve', it was found that the economic value of 'Regulating Services' (such as carbon sequestration, water provisioning and purification, soil conservation, nutrient retention, pollination, climate regulation, gene pool protection, waste assimilation, etc.)