D'Souza is best known for her portrayal of Sakshi Modi in Ek Nayi Pehchaan,[5][6] Raina Sharma in Brahmarakshas and Roopa Awasthi in Belan Wali Bahu.

In 2008, she appeared in Star Plus's Kasturi as Navneet and Kis Desh Mein Hai Meraa Dil as Veera.

In 2011, she portrayed Jeevika Vadhera in Ek Hazaaron Mein Meri Behna Hai opposite Karan Tacker.

In December 2013, she signed Sony TV's Ekk Nayi Pehchaan, playing Sakshi opposite Karan Sharma.

[citation needed] D'Souza was ranked 19th in the 50 Sexiest Asian Women List by Eastern Eye in 2013.