Kuakini Medical Center is a private hospital in Honolulu, Hawaii.

A larger facility was built in 1917 at the present site with donations from Emperor Taishō of Japan.

After the attack on Pearl Harbor in 1941, the US military occupied the hospital during World War II and renamed it Kuakini Medical Center, after the street.

[2] The street was in turn named for John Adams Kuakini (1791–1844) who was acting Governor of Oahu in the 1830s.

The hospital's Ewa wing and Waikiki wing had their construction financed by a major fundraising drive in 1951; Increasing the bed count of Kuakini to 140 beds.