Gonzalez's mother Victoria Quirino-Gonzalez, daughter of the former president, married shipping magnate Francisco Delgado after the death of his first wife.

Ledesma's husband, Louie Gonzalez, voluntarily surrendered to the Philippine National Bureau of Investigation on July 16, 2008, after an arrest warrant for murder and physical injuries was issued by the Manila Regional Trial Court Branch 32 Judge Thelma Medina amid the Court of Appeals' review of the case.

Gonzalez was arrested on March 10, 2007, for the killing of his stepbrother, Federico Delgado, who was found dead with multiple stab wounds.

Ledesma and her bandmates Toto Gentica and Jet Montelibano later went to Manila to form the Music & Magic band which became pivotal for her career.

In 1982, Ledesma launched an all-Filipino concert, 'Ako ay Pilipino' ("I am a Filipino") at the Cultural Center of the Philippines which featured a repertoire of ethnic sounds, classic kundimans and pop songs, tapping into the rich node of indigenous art and contemporary pop music to produce alternative approaches to songs.

During the political ambience of the 1980s, Ledesma paid tribute to Ninoy Aquino at the end of one of her shows at the Cultural Center of the Philippines by singing an a cappella rendition of "Impossible Dream" and "You'll Never Walk Alone (Hindi Ka Nagiisa)".

In March 1989, after competing with other top singers, Ledesma was selected to represent Asia at the Salem Music Awards at the Royal Albert Hall in London.

[citation needed] In 1991, Ledesma accepted an invitation to be a member of the panel of judges during the Miss Universe beauty pageant in Las Vegas.

Ledesma had a regular monthly television special called Akuhstic Café which is a musical travelogue that presented viewers the urban night life of Metro Manila by visiting clubs, lounges and concerts.

[citation needed] During the 2001 Philippine national elections, Ledesma was chosen by the PINATUBO (Pinag-isang Lakas Tungo sa Pagbabago) Party as a first nominee for congress.

[citation needed] In 2009, she went on a tour called A Love Affair with her daughter Isabella to New Zealand where she had a series of concerts in Auckland, Wellington, Christchurch and Hamilton.

She starred in her first TV soap, Bituin on ABS-CBN which premiered in September 2002 and appeared later on in Endless Love on GMA Network in June 2010.

In March 1990, Ledesma appeared as a guest performer in a Gilbert Becaud's television show in Paris where she sang "Bulaklak" ("The Flower") in three languages (Filipino, English and French).