The Kulfo River is a river in southern Ethiopia that rises in the western escarpment of the Main Ethiopian Rift in the Guge mountains.

It usually drains into Lake Chamo but can also drain into Lake Abaya after heavy rains through a bifurcation located directly southwest of Arba Minch Airport.

The overflow point is directly below an alluvial fan at an elevation of 1,190 m (at 6°00′39″N 37°35′07″E / 6.0109°N 37.5854°E / 6.0109; 37.5854).

The average diameter of the bed material is 14 mm (gravel).

[2] Cytotaxonomic analysis of larval chromosomes from the Kulfo River area has revealed the existence of two newly recognized species of Black flies in the river, Simulium kulfoense and S. soderense; yet unlike other Black flies these species are not carriers of Onchocerca volvulus.