[3] Sera Khandro was born into a rich family, but ran away at the age of 14 to escape an unwanted engagement, and to follow the Vajrayana teacher Drime Ozer, who was then in Lhasa on pilgrimage from Golok in Eastern Tibet.

[3] [4] Garra Gyelsel disliked her Terma revelations, and this caused Sera Khandro to become sick.

[4] From when she was young she had experienced visions of Vajravarahi and exhibited many confirming indications of being a treasure revealer, a Terton.

[2] In Sarah H. Jacoby's Love and Liberation: Autobiographical Writings of the Tibetan Buddhist Visionary Sera Khandro (New York: Columbia University Press, 2014), the author wrote Khandro was "one of the few Tibetan women to record the story of her life."

Khandro also wrote the biography of her guru, Drimé Özer,[5] son of the Terton Dudjom Lingpa.