The state institution was founded on 2 October 2006, based on the creation of the region territory as prescribed by Regulations No.

133 of the Cabinet of Ministers as of 25 March 2003, the "Regulations on Territories of Planning Regions".

[4] The territory of the Kurzeme Region was created in 2006 utilising and now includes: Dienvidkurzeme, Kuldīga, Saldus, Talsi, Tukums and Ventspils Districts as well as the cities of Liepāja and Ventspils.

As of 1 July 2009 the region consist of 6 municipalities and 2 cities within an area of 13,596 km2.

The Pedvale Open Air Museum, near Sabile is a national sculpture park.