Prior to his birth, Frimpong-Boateng's father, Kofi Frimpong, died from heart injuries sustained from a road accident.

[5] There were no cardiothoracic surgery facilities in the country at the time, so his aim for establishing the center was to train more surgeons and provide care to patients.

[6] He also served as head of the department of surgery at the school, prior to his appointment as the chief executive officer of the Korle-Bu Teaching Hospital in 2002.

In March 2006, Frimpong-Boateng announced his intention to seek the nomination as the candidate of the New Patriotic Party (NPP) for the December 2008 National Presidential Elections.

In November 2018, Frimpong-Boateng, address the World Summit Awards Grand in Accra, Ghana, and indicated his indicated his desire to use technology to transform the country.

Frimpong-Boateng runs a CNC machine tool centre that is able to produce spare parts with computer precision at the Free Zones enclave in the port city of Tema.