[1] It is bordered to the north by Uganda, to the east by Missenyi District, to the south by Karagwe District and to the west by Rwanda, and has an area of 2,575 square kilometres (994 sq mi).

[4][3] The district is home to the Ibanda-Kyerwa National Park.

The park is fed by the Kagera river that sustains animals such as hippos, leopards, antelope and buffalo.

[5] Unpaved trunk road T39 from Kayanga in Karagwe District to the Ugandan border passes through Kyerwa District from Omurushaka, Nkwenda, Isingiro, Kaisho to Murongo.

There is also unpaved road from Kayanga (administrative HQ for Karagwe district) via Rwambaizi, Katera, Businde, Bugomora, Nyamiyaga to Murongo.