In January 2020, on the opening day of the 2019–20 West Indies Championship, Mayers scored his maiden century in first-class cricket.

[5] In June 2020, Mayers was named as one of eleven reserve players in the West Indies' Test squad, for their series against England.

[11] In December 2020, Mayers was named in the West Indies' Test and One Day International (ODI) squads for their series against Bangladesh.

[18] In February 2022, Mayers was bought by the Lucknow Super Giants in the auction for the 2022 Indian Premier League tournament.

[21] Mayers made his IPL debut for Lucknow Super Giants against Delhi Capitals on 1 April 2023, scoring 73 off 38 balls, also bowling a single over.