It has long been known that many human cancers have higher LDHA levels compared to normal tissues.

It has also been shown that LDHA plays an important role in the development, invasion and metastasis of malignancies.

Mutations in LDHA have been linked to exertional myoglobinuria.

[6] Click on genes, proteins and metabolites below to link to respective articles.

[§ 1] The following compounds have been demonstrated to inhibit the LDHA enzyme: