10894114332ENSG00000133800ENSMUSG00000030787Q9Y5Y7Q8BHC0NM_006691NM_053247NP_006682NP_444477Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1), also known as extracellular link domain containing 1 (XLKD1) is a Link domain-containing hyaladherin, a protein capable of binding to hyaluronic acid (HA), homologous to CD44, the main HA receptor.

It acts as a receptor and binds to both soluble and immobilized hyaluronan.

This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis.

Expression of LYVE1 not restricted to lymph vessels but is also observed in normal liver blood sinusoids,[7] and embryonic blood vessels.

[9] [10] LYVE1 positive macrophages in the meninges of rats are both lymphatic, as well as, alymphatic.