Founded in 1903, the school is notable for producing several collegiate and professional athletes and was the national champion football team in 1991.

The town and high school derive their name from a connection to the French soldier and statesman, Marquis De Lafayette.

LaGrange High has produced professional athletes such as Mike Cameron, Dernell Stenson, Tony Stargell, Tyrone Poole, and Wesley Woodyard.

Sports offered are tennis, football, cross-country, track and field, cheerleading, basketball, golf, gymnastics, soccer, softball, swimming, volleyball, wrestling, and baseball.

"[6] In January 2010 the Atlanta Journal-Constitution bestowed "Best of the Decade" awards to Georgia Prep Football Teams based on results.