The Chicago Board of Trade Building, Willis Tower, and Harold Washington Library are nearby.

The first station on the site opened on October 10, 1852, with an extension of the Chicago and Rock Island Railroad from 22nd Street.

In December 1866 a new station opened, and the Michigan Southern and Northern Indiana Railroad joined the Rock Island as a tenant.

The LS&MS quickly gained control of the Nickel Plate, and later allowed it into its LaSalle Street Station as a tenant.

[4][5] During this period, the C&EI was operated by the St. Louis–San Francisco Railway, which was itself controlled by the Chicago, Rock Island and Pacific from 1901 to 1916.

The Rock Island ended intercity passenger service in 1978, but continued operating its commuter trains until handing them to the Chicago and North Western Railway in 1980.

[10] Of note, the Hickory Creek was the last car on the final run of the 20th Century Limited to leave LaSalle on December 3, 1967.

[12] It is planned that, in the future, Metra's SouthWest Service will be shifted from the Union Station to LaSalle Street.