La Caille is a lunar impact crater located in the rugged south-central highlands of the Moon.

Nearly attached to the southeast rim are the remains of Blanchinus, and the two are separated by a rugged stretch of terrain.

The floor of La Caille has been flooded in the past by lava, and the surface is relatively smooth and flat with no central rise.

Ray material lies across the central and southern parts of the floor, most likely from Tycho to the southwest.

By convention these features are identified on lunar maps by placing the letter on the side of the crater midpoint that is closest to La Caille.