Attacked by buccaneers and by the English, Dutch, and French armadas, La Guaira was transformed into a fortified, walled city.

In March 1743, in the Battle of La Guaira, the port was attacked without success by another English squadron of 19 ships under the command of Admiral Charles Knowles.

This period also saw the trading monopoly of the Royal Gipuzkoan Company of Caracas, which controlled the major ports of La Guaira and Puerto Cabello and was instrumental in the development of large-scale cocoa production along the valleys of the coast.

The English frigate HMS Hermione (1782) was delivered to the Spanish authorities at La Guaira after her crew mutinied in 1797.

The area provides the structure to deep-sea animals, and other organisms such as gorgonians, sponges, and coral, that require ocean currents to bring their food to them.