[6] The city of Trujillo was founded in 1557 by the conquistador and captain Diego García de Paredes, in honor of his homonymous and native town located in Extremadura, Spain.

It is also known as the Portable City because of its many foundations due to the fierce resistance of the indigenous people who inhabited that territory when defending their lands.

On 31 December 1676, Maracaibo (separated from the province of Venezuela) and Mérida-La Grita are united in a government, which includes in its territory the current state of Trujillo, called the Province of Mérida del Espíritu Santo of Maracaibo (capital in Mérida) dependent on the Audiencia of Bogotá.

On July 2, 1813, the patriots, under the command of Colonel José Félix Ribas, defeated the royalists in the battle of Niquitao in the framework of the Admirable Campaign.

On November 27, 1820, in the town of Santa Ana de Trujillo, Simón Bolívar and Captain General Pablo Morillo sign the Treaty of Armistice and Regularization of the War.

By means of these treaties the war to death was officially repealed, a truce of six months was agreed in addition to constituting a de facto recognition of the Great Colombia by the crown of Spain.

The railway line begins to lose importance in 1925 with the inauguration of the Trasandina Highway, as well as the progressive decrease of coffee production in Venezuela.

In the era of President Juan Vicente Gómez, the population of Trujillo was almost entirely foreign and commercial, but after its fall, its cultural development began.

The relief favors the formation of a series of local climates, where the winds play a very important role, penetrating the state from the northeast, as well as from the east.

Since 1989 the Governors are chosen in direct elections by the people, the current Trujillo Government is led by Henry Rangel Silva.

According to the 2011 Census, the racial composition of the population was:[7] The state bases its economic activity mainly on agriculture, which is complemented by other important sectors.

In the plain in contact with Lake Maracaibo or "low zone", specifically in jurisdiction of the municipalities of Andrés Bello, La Ceiba, Sucre, Bolívar and Monte Carmelo, and in the plains of Monay (municipality of Pampán), the highest proportion It comprises about 200,000 ha of land suitable for agricultural and forestry use for the cultivation of cereals,oilseeds,roots and tubers,vegetables and plantations and/or fruit trees.

One of the oldest irrigation systems and agricultural settlements in the country, El Cenizo, was built in this area and development programmes have been undertaken It is also located on the plain in the industrial zone of Agua Santa, of the same name as the Caús-Pocó, with fruit trees, cereals and an important Cattle farm.

In the plains of Monay, located in the north and east of the AguaViva, sugar cane production has a great competitive advantage due to its proximity to the La Pastora power station and the agronomic conditions of its soils.

The most prominent team is Trujillanos Fútbol Club, which plays in the first division of Venezuela and is based in the Estadio Olímpico José Alberto Pérez de Valera, where the much smaller Somos Escuque Fútbol Club, a third division team, also plays its matches.