LPH is owned and operated by Prime Healthcare Services (PHS), a hospital management company located in Victorville.

PHS was founded in 2001 by Prem Reddy, who acts as its present chairman of the board.

[2] LPH's operation under Catholic Healthcare West was short lived, when the Catholic system divested LPH and another nearby Orange County hospital, Martin Luther Hospital Anaheim, to MemorialCare Health Systems after less than a year under CHW control.

[2] MemorialCare Health Systems plans for LPH never came to fruition as the Long Beach-based non-profit sold the facility in December 1999 to for-profit Vanguard Health Systems, ending LPH's status as a non-profit facility.

[3] Prime Healthcare Services purchased La Palma Intercommunity Hospital on October 1, 2006, from Vanguard Health Systems, along with two other Orange County acute care facilities, West Anaheim Medical Center and Huntington Beach Hospital, in a $40 million transaction.