The place is named after La Reine Regiment (French for "the Queen"), that was founded in 1634 and fought under General Montcalm at the Battle of Carillon and Battle of Quebec.

[1] The first pioneers were from Berthier County and arrived in 1913, around the time when the National Transcontinental Railway was completed.

The train station was first designed as Okiko, derived from the Algonquin name for the La Reine River Okikadosag Sibi.

In 1917, the place was incorporated as the United Township Municipality of La Reine-et-Desmeloizes-Partie-Ouest.

[1] Municipal council (2024):[8] Notable people from La Reine include: