La Salle Secondary School, Kota Kinabalu (Malay: Sekolah Menengah La Salle Kota Kinabalu) is a co-educational secondary school for boys and girls (mostly boys) and one of the oldest schools in Kota Kinabalu on the coast of Borneo in East Malaysia.

The Junior Block (Forms 1 to 3) has been relocated to the new ground to accommodate the increase in student enrolment.

[1] In the early 1950s, the Catholic Mission started the Sacred Heart secondary school and Father Bernard Davies who served as its first principal.

In 1953, the Catholic Mission obtained 3 hectares of land in Tanjung Aru and moved the school to its present location.

This name was derived from the founder, Jean Baptiste de La Salle.