Sekolah Menengah Kebangsaan Pengiran Omar (abbreviated SMKPO) is a secondary school located at the town of Sipitang, in the Interior Division of the state of Sabah, Malaysia.

[1] This school has achieved several awards for their academic and co-curricular performance and have also broken a Malaysian record.

Its original site was in the middle of the Sipitang town.

In 1968, the building was destroyed by a typhoon, hence the classes had to be moved to the new buildings which were still under construction at that time, which location is between Kampung Menengah and Kampung Pelakat in 1973, the school was upgraded to a Government Secondary School and the school's name was changed to Sekolah Menengah Pengiran Omar Sipitang in order to commemorate the late Pengiran Omar bin Syaifuddin for donating the land where the school was built.

[3] On 6 April 2008 the school won 3rd place in the under 16 age category in the state finals.